Web Access Research Portal

Researcher: Fairfax, KA (Dr Kirsten Fairfax)

Fields of Research

Cell development, proliferation and death
Genetic immunology
Bioinformatic methods development
Medical molecular engineering of nucleic acids and proteins
Cancer genetics
Gene expression (incl. microarray and other genome-wide approaches)
Haematological tumours
Cellular immunology
Biochemistry and cell biology
Gene and molecular therapy
Immunogenetics (incl. genetic immunology)
Health services and systems
Implementation science and evaluation
Epigenetics (incl. genome methylation and epigenomics)
Medical and health law

Research Objectives

Clinical health
Diagnosis of human diseases and conditions
Expanding knowledge in the biomedical and clinical sciences
Citizenship and national identity
Treatment of human diseases and conditions
Other health
Prevention of human diseases and conditions
Law reform

Career Best Publications

Research Publications

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics; Nature Immunology
Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis; Cell Death and Differentiation
Assessing immune-related adverse events of efficacious combination immunotherapies in preclinical models of cancer; Cancer Research
BAFF-driven autoimmunity requires CD19 expression; Journal of Autoimmunity
CD19 differentially regulates BCR signalling through the recruitment of PI3K; Autoimmunity
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers; Journal of Autoimmunity
Fluorescent antibiotics, vomocytosis, vaccine candidates and the inflammasome; Clinical & Translational Immunology
Functional genomics for curation of variants in telomere biology disorder associated genes: A systematic review; Genetics in Medicine
Functional genomics for curation of variants in telomere biology disorder associated genes: A systematic review; Genetics in Medicine
Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion; Journal of Immunology
Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans; Nucleic Acids Research
Haemopedia: an expression atlas of murine hematopoietic cells; Stem Cell Reports
Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia; Cancer Cell
Identification of a Siglec-F+ granulocyte-macrophage progenitor; Journal of Leukocyte Biology
IL-10 regulates Aicda expression through miR-155; Journal of Leukocyte Biology
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells; The Journal of Experimental Medicine
Single cell eQTL mapping identifies cell type specific genetic control of autoimmune disease; Science
The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells; Immunology and Cell Biology
The RNA-binding protein HuR (Elavl1) is essential for the B cell antibody response; Nature Immunology
The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice; Science Signaling
Transcriptional profiling of eosinophil subsets in interleukin-5 transgenic mice; Journal of Leukocyte Biology

Research Projects

Advancing Precision Medicine for Families with Haematological Malignancy; Royal Hobart Hospital Research Foundation (RHHRF)
Examining the how and why of blood cell gene regulation at loci relevant to autoimmune disease; National Health & Medical Research Council (NHMRC)
Functional interrogation of loci associated with the regulation of haematopoiesis; Maddie Riewoldt's Vision (MRV)
PAGETURNA: Pioneering Application of Gene Editing to Transplant Using RNA; Medical Research Future Fund (MRFF)
Uncovering genetic and epigenetic drivers of gene expression changes in blood cells; Maddie Riewoldt's Vision (MRV)

Research Candidate Supervision