Web Access Research Portal

Researcher: Vincent, AJ (Dr Adele Vincent)

Fields of Research

Cellular Nervous System
Central Nervous System
Neurosciences
Neurology and Neuromuscular Diseases
Cell Neurochemistry
Animal Physiology - Cell
Sensory Systems
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Cell Development, Proliferation and Death

Research Objectives

Nervous System and Disorders
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Environmental Sciences
Expanding Knowledge in the Medical and Health Sciences
Health

Career Best Publications

Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity; Journal of Alzheimer's Disease
Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells; Glia
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Morphological and functional plasticity of olfactory ensheathing cells; Journal of Neurocytology
Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1; Glia
SPARC is expressed by macroglia and microglia in the developing and mature nervous system; Developmental Dynamics

Research Publications

A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster); 12th International Conference on Alzheimerís and Parkinsonís Diseases
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; The International Neurotrauma Symposium
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; International Society of Neuroimmunology
Analysis of Aβ cell interactions and uptake in hippocampal culture; 32nd Annual Meeting of the Australian Neuroscience Society
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity; Journal of Alzheimer's Disease
Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells; Glia
Do microglia default on network maintenance in Alzheimer's disease?; Journal of Alzheimer's Disease
Do olfactory ensheathing cells play a role in the defense of the brain against infection?; Neuroembryology and Aging
Encapsulated olfactory ensheathing cells in spinal cord repair; International Society for Developmental Neuroscience
Gene expression profile of rat olfactory ensheathing cells; The International Neurotrauma Symposium
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc; American Journal of Physiology
Morphological and functional plasticity of olfactory ensheathing cells; Journal of Neurocytology
Morphological plasticity of olfactory ensheathing cells; Australian Neuroscience Society
Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1; Glia
Morphological plasticity of olfactory ensheathing cells is regulated by cyclic AMP and endothelin-1; Symposium on Neural Regeneration
Olfactory ensheathing cell-produced SPARC modulates Schwann cell activation to promote neurite outgrowth and spinal cord repair; Journal of Neuroscience
Olfactory ensheathing cells display antimicrobial activity in culture and may contribute to the innate immune defense of the olfactory system; Australian Neuroscience Society
Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue; The International Neurotrauma Symposium
Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord; Experimental Neurology
Olfactory ensheathing cells promote collateral axonal branching in the lesioned adult rat spinal cord; Symposium on Neural Regeneration
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; 21st Annual National Neurotrauma Society Symposium
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; Society for Neuroscience Annual Meeting
Pathogens induce nitric oxide production by olfactory ensheathing cells; 7th IBRO World Congress of Neuroscience
Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue; The Australian Neuroscience Society
Response of neurons to injury in coculture with olfactory ensheathing cells; International Society for Developmental Neuroscience
SPARC is expressed by macroglia and microglia in the developing and mature nervous system; Developmental Dynamics
SPARC regulates microgliosis and functional recovery following cortical ischemia; Journal of Neuroscience
Spinal cord tissue affects ensheathing cell proliferation and apoptosis; NeuroReport
The global gene expression of olfactory ensheathing cells and comparisons to astrocytes and Schwann cells; The Australian Neuroscience Society
The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons; Journal of Neuroscience Research
The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease; Journal of Alzheimer's Disease
TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons; Molecular Neurodegeneration
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; 21st Annual National Neurotrauma Society Symposium
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; Society for Neuroscience Annual Meeting
Whole bacteria, but not specific ligands for Toll-like receptors 2 or 4, activate NF kB and cytokine production in olfactory ensheathing cells in vitro; Society for Neuroscience

Research Projects

Are microglia the villains of AB toxicity in Alzheimer's disease; Dementia Australia Research Foundation Ltd (DARF)
Determining the biological consequences of Abeta binding to neurons in Alzheimer's Disease; The Select Foundation (SelF)
Do calcium blocker drugs prevent Alzheimer's disease in a transgenic mouse model? ; Dementia Australia Research Foundation Ltd (DARF)
The role of SPARC in regeneration and neurogenesis in the central nervous system (Australia); National Health & Medical Research Council (NHMRC)

Research Candidate Supervision

Role of Phosphoinositides in the Biology of the Amyloid Precursor Protein