Web Access Research Portal

Researcher: Chung, RS (Associate Professor Roger Chung)

Fields of Research

Central Nervous System
Cellular Nervous System
Neurology and Neuromuscular Diseases
Cell Neurochemistry
Neurosciences
Respiratory Diseases
Peripheral Nervous System
Epidemiology
Autonomic Nervous System
Biochemistry and Cell Biology
Tumour Immunology
Cellular Immunology
Allergy
Systems Biology
Cancer Cell Biology
Clinical Nursing: Secondary (Acute Care)
Molecular Targets
Sensory Systems
Animal Physiology - Systems
Medical and Health Sciences
Medical Biotechnology
Otorhinolaryngology
Oncology and Carcinogenesis

Research Objectives

Nervous System and Disorders
Neurodegenerative Disorders Related to Ageing
Diabetes
Health
Expanding Knowledge in the Environmental Sciences
Cancer and Related Disorders
Respiratory System and Diseases (incl. Asthma)
Clinical Health (Organs, Diseases and Abnormal Conditions)
Expanding Knowledge in the Biological Sciences
Disease Distribution and Transmission (incl. Surveillance and Response)
Health Related to Ageing
Immune System and Allergy
Environmental Education and Awareness
Expanding Knowledge in the Medical and Health Sciences
Coastal and Estuarine Flora, Fauna and Biodiversity
Skin and Related Disorders

Career Best Publications

A role for extracellular metallothioneins in CNS injury and repair; Neuroscience
Metallothionein based neuronal therapeutics and therapeutic methods
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury; Journal of Neurochemistry
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One

Research Publications

In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
A model of metallothionein action in the injured brain; Metals and Metallothionein in Biology and Medicine
A rat spinal lesion model to investigate olfactory ensheathing cell transplantation in CNS injury; Combio, 2000
A role for ERM proteins and extracellular guidance cues in neuronal movement and the response to trauma
A role for extracellular metallothioneins in CNS injury and repair; Neuroscience
Acute reactive and regenerative changes in mature cortical axons following injury; Neuoreport
ALS-like axonal pathology in cultured spinal motor neurons; 18th Symposium on ALS/MND
ALS-like pathology in cultured spinal motor neurons following excitoxicity; IBRO International Conference
An extracellular role for metallothionein in recovery from brain injury; Symposium on Neural Regeneration
An extracellular role for metallothoinein in recovery from brain injury; 23rd Annual Meeting of the Australian Neuroscience Society
Axonopathy, excitotoxicity and neuronal degeneration in ALS 2008; Australian Neuroscience Society Conference
Cyclosporin - a treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury; Developmental Neurobiology
Disruption of the Ubiquitin Proteasome System following Axonal Stretch Injury Accelerates Progression to Secondary Axotomy; Journal of Neurotrauma
Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice; Histology and histopathology
Does metallothionein attenuate mutant SOD1 aggregation in MND; 22nd Symposium on ALS/MND
Encapsulated olfactory ensheathing cells in spinal cord repair; International Society for Developmental Neuroscience
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons; European Journal of Neuroscience
Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain; PLoS ONE
Extracellular, neuroactive properties of metallothioneins; Society for Neuroscience
Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro; Experimental Neurology
Identification and characterization of a population of motile neurons in long-term cortical culture; Cell Motility and the Cytoskeleton
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice; Journal of Neuroinflammation
Injury to neurons induces metallothionein expression in adjacent astrocytes: role of soluble factors; 21st Annual National Neurotrauma Society Symposium
Localisation of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity; Journal of Comparative Neurology
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury; Pl o S One
Metallothionein based neuronal therapeutic and therapeutic methods
Metallothionein based neuronal therapeutic and therapeutic methods
Metallothionein based neuronal therapeutics and therapeutic methods
Metallothionein biology in the ageing and neurodegenerative brain; Neurotoxicity Research
Metallothionein expression by NG2 glial cells following CNS injury; Cellular and Molecular Life Sciences
Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways ; Experimental Neurology: A Journal of Neuroscience Research
Metallothionein induction following neuronal injury reveals neuron - astrocyte interactions; Society for Neuroscience Annual Meeting
Metallothionein plays an important role in brain-injury induced reactive astrogliosis; 8th International Neurotrauma Symposium
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy; Cellular and Molecular Life Sciences
Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury ; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Metallothionein-IIA promotes neurite growth via the megalin receptor; Experimental Brain Research
Metallothionein-III Inhibits Initial Neurite Formation in Developing Neurons as Well as Postinjury, Regenerative Neurite Sprouting; Experimental Neurology
Metallothioneins as a model for investigating neuron-astrocyte iinteractions following CNS injury; Congress of the International Society for Neurochemistry
Metallothioneins I and II: neuroprotective significance during CNS patholgoy; The International Journal of Biochemistry & Cell Biology
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy; Journal of Neurotrauma
Murine spinal neurons in vitro develop proximal axonal transport abnormalities and swellings that are similar to early axonal changes in amyotrophic lateral sclerosis; Society for Neuroscience
Neuorn-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; Symposium on Neural Regeneration
Neuron-astrocyte interactions following brain injury activate a novel, metallothionein-based neuroprotective mechanism; The Australian Neuroscience Society
Neuron-astrocyte interactions following neuronal injury activate a novel, metallothionein based neuroprotective mechanism; The International Neurotrauma Symposium
Neuron-astrocyte signalling regulates astrocytic expression of neuroprotective metallothionein protein following neuronal injury; Asia-Pacific Society for Neurochmistry
Neuron-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; First Joint Symposium of the National and International Neurotrauma Societies
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury; Journal of Neurochemistry
Neuron-glia interaction and metallothionein expression in a culture model of axonal injury; The Australian Neuroscience Society
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology; Neurobiology of Aging: Experimental and Clinical Research
Neuron-glia interactions underlying axonal health in an in vitro spinal culture model of relevance to ALS; 19th Symposium on ALS/MND
Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain ; The F E B S Journal
Neuronally released factors induce metallothionein in neighbouring astrocytes following injury; Combio 2003
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins; Journal of Biological Inorganic Chemistry
New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration; Journal of Neurochemistry
Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis; Society for Neuroscience
Olfactory ensheathing cells are attracted to, and are capable of phagocytosing bacteria; The 28th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells are attracted to, and can endocytose, bacteria; Cellular and Molecular Life Sciences
Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue; The International Neurotrauma Symposium
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ; Molecular and Cellular Neuroscience
Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord; Experimental Neurology
Olfactory ensheathing cells promote collateral axonal branching in the lesioned adult rat spinal cord; Symposium on Neural Regeneration
Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors; Cellular and Molecular Life Sciences
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; 21st Annual National Neurotrauma Society Symposium
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; Society for Neuroscience Annual Meeting
Peripheral effects of metallothionein in brain injury: Altered immune system response in metallothionein-1/2 null mice; 4th International Congress on Stress Responses in Biology and Medicine
Production of neuro-active metallothionein-III isoforms and assay of their action in a rat model of cortical damage; Combio, 2000
Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue; The Australian Neuroscience Society
Prolonged Aβ treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca+ homeostasis; Molecular Neurodegeneration
Protective role of metallothioneins in the injured mammalian brain
Protective role of metallothioneins in the injured mammalian brain; Reviews in the Neurosciences
Recent insights into the neuroprotective role of metallothionein in the injured brain; The Australian Neuroscience Society
Recent rodent models for Alzheimer's disease: Clinical implications and basic research; Journal of Neural Transmission
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry
Redox-active Cu(II)Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner; Experimental Neurology
Relationship between the developmental localisation of glutamate receptor subunits in vitro and susceptibility to excitotoxicity; Australian Neuroscience Society Conference
Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III; Biochemical Journal
Spinal cord tissue affects ensheathing cell proliferation and apoptosis; NeuroReport
Tg2576 cortical neurons that express human Aβ are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration ; PL o S One
The global gene expression of olfactory ensheathing cells and comparisons to astrocytes and Schwann cells; The Australian Neuroscience Society
The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration; Journal of Neuroinflammation
The link between cellular changes associated with axonal injury and Alzheimer's Disease; The International Neurotrauma Symposium
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One
The role of extracellular metallothionein in CNS injury
The role of extracellular metallothionein in cortical wound healing; 23rd Annual Meeting of the Australian Neuroscience Society
The Role of Metallothionein and Astrocyte-Neuron Interactions in Injury to the CNS; Metallothioneins in Biochemistry and Pathology
The role of metallothionein in brain-injury induced reactive astrogliosis; 7th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival
Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro; Journal of Cellular and Molecular Medicine
Understanding excitotoxicity and neuron death: focus upon the axonal cytoskeleton; The Australian Neuroscience Society
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; 21st Annual National Neurotrauma Society Symposium
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; Society for Neuroscience Annual Meeting
Zn(II)- and Cu(II)- induced non-fibrillar aggregates of amyloid- (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators; Journal of Neurochemistry

Research Projects

Assessing the Ability of Metallothionein to Promote Functional Recovery in an Animal Model of Traumatic Spinal Cord Injury; Royal Hobart Hospital Research Foundation (RHHRF)
Can Metallothionein Protect Against Axonal Degeneration Following Traumatic Brain Injury?; Clive & Vera Ramaciotti Foundation (CVRF)
Cellular mechanisms that protect against copper-bound beta-amyloid; Australian Research Council (ARC)
Developing metallothioneine as a therapeutic agent for the treatment of traumatic brain injury; MAIB Injury Prevention & Management Foundation (MAIB)
Developing Metallothioneins as a Therapeutic Agent for Promoting Neuronal Recovery from CNS Injury or Neurodegenerative Disease; National Health & Medical Research Council (NHMRC)
DNA Microarray Analysis to Identify Molecular Mechanisms that Regulate Astrocyte Function in Response to Traumatic Brain Injury; University of Tasmania (UTAS)
Effect of metallothionein and exercise on progression of motor neurone disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems; Australian Research Council (ARC)
Establishment of a Fluorescent Stereo-microscope Facility to Determine the Ability of Mature Neurons to Recover from Trauma; National Health & Medical Research Council (NHMRC)
Excitotoxicity and Cytoskeletal Alterations in the Pathogenesis of Motor Neurone Disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
How does the LRP receptor megalin promote regenerative neuronal growth?; National Health & Medical Research Council (NHMRC)
Identifying the Specific Structural Features of Metallothionein that Regulate its Ability to Modulate Astrogliosis; Australian Research Council (ARC)
Interactions between injured neurons, astrocytes and metallothionein; National Health & Medical Research Council (NHMRC)
Investigating the role of metallothionein in ultraviolet radiation-induced skin cancer; Cancer Council of Tasmania (CCT)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Luminometry System; National Health & Medical Research Council (NHMRC)
Mechanism of Metallothionein Action on Injured Neurons; Royal Hobart Hospital Research Foundation (RHHRF)
Metallothionein-based Neuroprotection in a Transgenic Mouse Model of Motor Neurone Disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Metallothionein-based therapeutic for Alzheimer's Disease; Dementia Australia Research Foundation Ltd (DARF)
Modulating beta-amyloid aggregation and toxicity with natural metal-binding proteins; National Health & Medical Research Council (NHMRC)
Redefining the Metallothionein's role in the Injured Brain: Extracellular Metallothioneins Play an Important Role in Astrocyte-neuron Responses to Injury; Australian Research Council (ARC)
Rising Stars Programme - Roger Chung; University of Tasmania (UTAS)
Role of vitamin D3 and metallothionein in protection against melanoma; Cancer Council of Tasmania (CCT)
The role of excitotoxicity in mediating distal axonal degeneration in ALS; National Health & Medical Research Council (NHMRC)
Travel to Attend the 8th International Neurotrauma Symposium in Rotterdam, The Netherlands, 21-25 May 2006; Ian Potter Foundation (IPF)
Understanding Excitotoxicity and Neuron Death: Focus Upon The Axonal Cytoskeleton; University of Tasmania (UTAS)
Unravelling the cellular pathology underlying neuronal degeneration in motor neuron disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Using Metallothioneins as a Model for Understanding Cellular and Biochemical Interactions between Neurons and Astrocytes within the Brain; Australian Research Council (ARC)
Visualising neuron-glia interactions in the injured central nervous system; Australian Research Council (ARC)
Enhancement of capacity in Neuro regeneration and repair research

Research Candidate Supervision

Elucidating the Roles of Aurora B Kinase in Neurons
Evaluation of Antioxidant and Neuroprotective Therapies in a Mouse Model of Amyotrophic Lateral Sclerosis
Immune System Modulation in the Brain Injury of the Metallothionein-I/II null Mutant Mouse
Interactions Between Metallathionein and Neurons of the CNS
Investigating the Potential Theraputic Value of Metallothionein-Like Derivatives in Neurodegenrative Disorders
Investigation of the therapeutic potential of metallothionein IIA in a model of motor neurone disease, the G93A SOD1 transgenic mouse
Metallothionein release from astrocytes in the brain and culture as a response to injury
The Role of Metallothionein I/II in Promoting Axonal Sprouting in Both Central Nervous System and Peripheral Nervous System
Unravelling the Cellular Pathology Leading to Neurodegeneration in Motor Neurone Disease
Unravelling the Molecular and Cellular Mechanisms Contributing to Secondary Axonal Degeneration Following Traumatic Brain Injury