Web Access Research Portal

Researcher: Sallis, JD (Dr John Sallis)

Fields of Research

Colloid and surface chemistry
Nephrology and urology
Other chemical sciences
Health services and systems
Rheumatology and arthritis
Instrumental methods (excl. immunological and bioassay methods)
Medicinal and biomolecular chemistry
Medical biochemistry and metabolomics
Cell metabolism
Biochemistry and cell biology
Pharmacology and pharmaceutical sciences
Structure and dynamics of materials
Organic chemical synthesis
Clinical pharmacology and therapeutics
Mineralogy and crystallography
Other biological sciences
Analytical chemistry

Research Objectives

Other health
Expanding knowledge in the chemical sciences
Clinical health
Expanding knowledge in the environmental sciences
Human pharmaceutical treatments
Expanding knowledge in philosophy and religious studies

Career Best Publications

Research Publications

Calcium pyrophosphate crystal salt forms and the influence of phosphocitrate; Advances in Crystal Growth Inhibition Technologies
Controlling influence of phosphocitrate in vitro and in vivo on calcium oxalate crystal formation and growth; Scanning Microscopy
Crystal growth and molecular modeling studies of inhibition of struvite by phosphocitrate; Calcified Tissue International
Distribution of phosphocitrate after intravenous administration to the rat; Ninth International Symposium on Urolithiasis
In vitro and modeling studies of struvite-inhibitor interactions; Urolithiasis 1996
In vitro calcium oxalate monohydrate (COM) agglomeration [tm] and percent crystal growth (%GI) inhibited by phosphocitrate (PC) addition to stone former urines; Urolithiasis 1996
In vitro prevention of struvite encrustation on catheter material with phosphocitrate; Urolithiasis 1996
Kidney selective prodrugs of phosphocitrate: Synthesis and in vivo hydrolysis of gamma-glutamyl derivatives of phosphocitrate and their in vivo influence on nephrocalcinosis; Pharmaceutical Sciences
Liposome and multiple emulsion formulations augment the anticalcifying efficacy of phosphocitrate in a cutaneous calcergy model; Journal of Pharmacy and Pharmacology
Phosphocitrate inhibits a basic calcium phosphate and calcium pyrophosphate dihydrate crystal-induced mitogen-activated protein kinase cascade signal transduction pathway; The Journal of Biological Chemistry
Phosphocitrate: Potential to Influence Deposition of Scaling Salts and Corrosion; Mineral Scale Formation and Inhibition
Quantification of prothrombin mRNA using competitive polymerase chain reaction; Ninth International Symposium on Urolithiasis
Scanning electron microscopy and molecular modeling of inhibition of calcium oxalate monohydrate crystal growth inhibition by citrate and phosphocitrate; Calcified Tissue International
Specific inhibition of basic calcium phosphate and calcium pyrophosphate crystal-induction of metalloproteinase synthesis by phosphocitrate; Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Research Projects

Antiscaling treatment with surface active phosphocitrate microspheres; Australian Research Council (ARC)
Bioavailability of phosphocitrate from oral delivery; Proctor & Gamble Company (P&G)
Chemical and computer modelling studies of crystallite-inhibitor interactions to predict an ideal inhibitor; Australian Research Council (ARC)
Continuing studies on control of calcium pyrophosphate crystallization by phosphocitrate; Australian Research Council (ARC)
Designing crystallite inhibitors from computer and experimental data; Australian Research Council (ARC)
Development of Strategies to Synthesize Polymeric Phosphocitrate Analogues for Industrial Scale Control; Australian Research Council (ARC)
Evaluation of the potential of phosphocitrate polymer material to reduce industrial scale formation; Australian Research Council (ARC)
Fundamental and Applied Studies in High Performance Ion Chronatography; Australian Research Council (ARC)
Fundamental and Applied Studies in High Performance Ion Chronatography; University of Tasmania (UTAS)
Growth inhibition of struvite and calcium pyrophosphate crystals by phosphocitrate.; Australian Research Council (ARC)
Targeted lithiasis control via prodrugs of phosphocitrate or its analogue; National Health & Medical Research Council (NHMRC)

Research Candidate Supervision

Biochemical pharmaceutics
Development and evaluation of compounds with anti-calcification properties
Development of an oral phosphocitrate prodrug to control calcinosis
Microsphere preparations as carriers of phosphocitrate for pathological mineralisation therapy
Muscle fuel uptake- a result of hormone and substrate interaction affecting regional blood flow
Nutritive and Non-Nutritive Blood Flow in Muscle
Regulation of skeletal muscle metabolism
Relationship of microvascular flow distibution to skeletal muscle metabolism
TITLE- Studies on the oral delivery of phosphocitrate
Vascular & metabolic actions of insulin