Fields of Research

Cancer genetics
Molecular targets
Epigenetics (incl. genome methylation and epigenomics)
Ophthalmology
Medical genetics (excl. cancer genetics)
Cancer cell biology
Cancer diagnosis
Predictive and prognostic markers
Solid tumours
Gene mapping
Epidemiology
Oncology and carcinogenesis
Disease surveillance
Genomics
Cancer therapy (excl. chemotherapy and radiation therapy)
Gene expression (incl. microarray and other genome-wide approaches)
Radiation therapy
Cellular nervous system
Aboriginal and Torres Strait Islander public health and wellbeing
Preventative health care
Genome structure and regulation
Cardiology (incl. cardiovascular diseases)
Health surveillance
Medical biochemistry - amino acids and metabolites
Health promotion
Foetal development and medicine

Research Objectives

Clinical health
Diagnosis of human diseases and conditions
Treatment of human diseases and conditions
Expanding knowledge in the biomedical and clinical sciences
Men's health
Evaluation of health and support services
Evaluation of health outcomes
Disease distribution and transmission (incl. surveillance and response)
Behaviour and health
Allied health therapies (excl. mental health services)
Social structure and health
Efficacy of medications
Health related to ageing
Preventive medicine

Career Best Publications

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease; Human Molecular Genetics
Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features; Clinical Cancer Research
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci; Nature Genetics
Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer; BMC Cancer
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation; Nature communications
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants; Nature Communications
Genetic Variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF Genes Are Prognostic Markers of Prostate Cancer-Specific Mortality; Cancer Epidemiology, Biomarkers and Prevention
Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer; Cancer Epidemiology, Biomarkers and Prevention
Genome-wide measures of peripheral blood DNA methylation and prostate cancer risk in a prospective nested case-control study; The Prostate
Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility; Cancer Epidemiology, Biomarkers and Prevention
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array; Nature Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours; Scientific Reports
National Cancer Institute Prostate Cancer Genetics Workshop; Cancer Research
Novel common genetic susceptibility loci for colorectal cancer; Journal of the National Cancer Institute
Obtaining high quality transcriptome data from formalin-fixed, paraffin-embedded diagnostic prostate tumor specimens; Laboratory Investigation
Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status; Human Molecular Genetics
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study; Nature Genetics
Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study; Cancer Research

Research Publications

A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: development and validation studies; The Prostate
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease; Human Molecular Genetics
A rare variant in EZH2 is associated with prostate cancer risk; International Journal of Cancer
A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease; Cancer Medicine
Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study; International Journal of Cancer
Analysis of a large prostate cancer family identifies novel and recurrent gene fusion events providing evidence for inherited predisposition; Prostate
Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features; Clinical Cancer Research
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels; International Journal of Cancer
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci; Nature Genetics
Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease; Human Genetics
Association of a novel BRCA2 mutation with prostate cancer risk further supports germline genetic testing; European Journal of Cancer
Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis; Prostate Cancer and Prostatic Diseases
Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer; BMC Cancer
Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases; Human Genetics
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation; Nature communications
Blood lipids and prostate cancer: a Mendelian randomization analysis; Cancer Medicine
Broad Phenotypic variability in a Single Pedigree With a Novel 1410delC Mutation in the PST Domain of the PAX6 Gene; Human Mutation
Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG; The Prostate
Clinical Utility of Five Genetic Variants for Predicting Prostate Cancer Risk and Mortality; The Prostate
Comparing vision and macular thickness in neovascular age-related macular degeneration, diabetic macular oedema and retinal vein occlusion patients treated with intravitreal antivascular endothelial growth factor injections in clinical practice; BMJ Open Ophthalmology
Cumulative burden of colorectal cancer-associated genetic variants is more strongly associated with early-onset vs late-onset cancer; Gastroenterology
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries; Nature Genetics
Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage; Human Molecular Genetics
Discovery of common and rare genetic risk variants for colorectal cancer; Nature Genetics
Does the Addition of Information on Genotype Improve Prediction of the Risk of Melanoma and Nonmelanoma Skin Cancer beyond That Obtained from Skin Phenotype?; American Journal of Epidemiology
Effect of MELANOTAN1, [Nle4 , D-Phe7 ]-a-MSH, on melanin synthesis in humans with MC1R variant alleles; Peptides
Evaluation of hypofractionated radiation therapy use and patient-reported outcomes in men with nonmetastatic prostate cancer in Australia and New Zealand; JAMA Network Open
Evidence for a Novel Type 1 Diabetes Susceptibility Locus on Chromosome 8; Diabetes
Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus; Human Molecular Genetics
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants; Nature Communications
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array; British Journal of Cancer
Genetic Variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF Genes Are Prognostic Markers of Prostate Cancer-Specific Mortality; Cancer Epidemiology, Biomarkers and Prevention
Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21; Human genetics
Genome-wide association study identifies a genetic variant associated with risk for more aggressive prostate cancer; Cancer Epidemiology, Biomarkers and Prevention
Genome-Wide Association Study of Prostate Cancer–Specific Survival; Cancer Epidemiology, Biomarkers and Prevention
Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14; European Journal of Human Genetics
Genome-wide measures of DNA methylation in peripheral blood and the risk of urothelial cell carcinoma: a prospective nested case-control study; British Journal of Cancer
Genome-wide measures of peripheral blood DNA methylation and prostate cancer risk in a prospective nested case-control study; The Prostate
Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types; Cancer Discovery
Genotypic and phenotypic spectrum of X-linked retinoschisis in Australia; Clinical and Experimental Ophthalmology
Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility; Cancer Epidemiology, Biomarkers and Prevention
Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: an analysis of 12,082 prostate cancer cases; Prostate Cancer and Prostatic Diseases
Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium; British Journal of Cancer
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array; Nature Genetics
Identification of a novel recurrent EEF2 gene amplification in familial prostate tumors; Genes, Chromosomes and Cancer
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease; European Journal of Human Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Identifying genetic biomarkers predicting response to anti-vascular endothelial growth factor injections in diabetic macular edema; International Journal of Molecular Sciences
Identifying genetic risk factors for diabetic macular edema and the response to treatment; Journal of Diabetes Research
Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours; Scientific Reports
Interest in genetic testing among affected men from hereditary prostate cancer families and their unaffected male relatives; Genetics in Medicine
Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis; International Journal of Cancer
Investigation of the prevalence of the myocilin Q368STOP mutation in Ugandan glaucoma patients; Ophthalmic Genetics
Investigation of the Relationship Between Prostate Cancer and MSMB and NCOA4 Genetic Variants and Protein Expression; Human Mutation
Linkage analysis of a second large prostate cancer family from southern Tasmania, Australia; American Society of Human Genetics Conference
Massively parallel sequencing in hereditary prostate cancer families reveals a rare risk variant in the DNA repair gene, RAD51C; European Journal of Cancer
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans; Human Molecular Genetics
Mutations in a Novel Gene, NHS, Cause the Pleiotropic Effects of Nance-Horan Syndrome, Including Severe Congenital Cataract, Dental Anomalies, and Mental Retardation; American Journal of Human Genetics
Mutations in the NDP gene: contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity; Clinical and Experimental Ophthalmology
National Cancer Institute Prostate Cancer Genetics Workshop; Cancer Research
Novel associations between blood DNA methylation and body mass index in middle-aged and older adults; International Journal of Obesity
Novel common genetic susceptibility loci for colorectal cancer; Journal of the National Cancer Institute
Obtaining high quality transcriptome data from formalin-fixed, paraffin-embedded diagnostic prostate tumor specimens; Laboratory Investigation
Pharmacogenomic biomarkers in docetaxel treatment of prostate cancer: from discovery to implementation; Genes
Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium; British Journal of Cancer
Prediction of Individual Genetic Risk to Prostate Cancer Using a Polygenic Score; PRACTICAL consortium; The Prostate
Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status; Human Molecular Genetics
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort; BMC Medicine
Rare germline variants in ATM predispose to prostate cancer: A PRACTICAL Consortium study; European Urology Oncology
Re: Daniel J. Lee, Ryan Hausler, Anh N. Le, et al. Association of inherited mutations in DNA repair genes with localized prostate cancer. Eur Urol 2022;81:559-67; European Urology
Reliability of DNA methylation measures from dried blood spots and mononuclear cells using the HumanMethylation450k BeadArray; Scientific Reports
Risk analysis of prostate cancer in PRACTICAL, a multinational consortium, using 25 known prostate cancer susceptibility loci; Cancer Epidemiology, Biomarkers and Prevention
Sequence variants of α-methylacyl-CoA racemase are associated with prostate cancer risk: A replication study in an ethnically homogeneous population; The Prostate
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study; Nature Genetics
Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study; Cancer Research
The advantages of dense marker sets for linkage analysis with very large families; Human Genetics
The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus; BMC Ophthalmology
The OncoArray Consortium: a network for understanding the genetic architecture of common cancers; Cancer Epidemiology, Biomarkers and Prevention
Tools for translational epigenetic studies involving formalin-fixed paraffin-embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population-based studies; BMC Research Notes
Two-stage study of familial prostate cancer by whole-exome sequencing and custom capture identifies 10 novel genes associated with the risk of prostate cancer; European Urology
Urban–rural prostate cancer disparities in a regional state of Australia; Scientific Reports
Use of a novel non-parametric version of DEPTH to identify genomic regions associated with prostate cancer risk; Cancer Epidemiology, Biomarkers and Prevention
Use of Aspirin and Other Nonsteroidal Antiinflammatory Medications in Relation to Prostate Cancer Risk; American Journal of Epidemiology
Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG); Human Genetics
Whole exome sequencing in 75 high-risk families with validation and replication in independent case-control studies identifies TANGO2, OR5H14, and CHAD as new prostate cancer susceptibility genes; OncoTarget
WORK IT: Gender equality under the microscope

Research Projects

A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania; Cancer Council of Tasmania (CCT)
A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania; Royal Hobart Hospital Research Foundation (RHHRF)
A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania; Royal Hobart Hospital Research Foundation (RHHRF)
A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania; Royal Hobart Hospital Research Foundation (RHHRF)
Advancing Precision Medicine for Men Diagnosed with Prostate Cancer; Perpetual Trustees (PT)
Applying innovative 'omics' technologies to identify key molecular drivers of metastatic bone tumours; Cancer Council of Tasmania (CCT)
Cancer Council Tasmania/College of Health and Medicine Postdoctoral Fellowship; Cancer Council of Tasmania (CCT)
DNA Damage Repair Gene Variants in Clinically Significant Prostate Cancer; Cancer Council of Tasmania (CCT)
Enhancing PCOR-ANZ using Data Linkage: A Pathfinder Pilot; Movember Foundation (MoF)
Gaining new insights into metastatic bone tumours; Royal Hobart Hospital Research Foundation (RHHRF)
Identification of Genomic Regions Implicated in Hereditary Prostate Cancer in Tasmania by Genome-wide Scan; Royal Hobart Hospital Research Foundation (RHHRF)
Inherited genes in prostate cancer: addressing the gaps in our understanding; University of Tasmania (UTAS)
Investigation of chromosomal loss and gain at 7p21 in a Tasmanian hereditary prostate cancer family; Royal Hobart Hospital Research Foundation (RHHRF)
Is EEF2 a potential biomarker for more aggressive prostate cancer in Tasmanian patients?; Royal Hobart Hospital Research Foundation (RHHRF)
Less is More - Evaluating and Enhancing the Adoption of Short-course Radiotherapy in Australia (EASY-AUS); Movember Foundation (MoF)
Precision Medicine for Men with Prostate Cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Real-world outcomes and toxicities for patients with non-small cell lung cancer receiving immunotherapy; Royal Hobart Hospital Research Foundation (RHHRF)
Understanding the life course relationship of DNA methylation with obesity traits and its association with obesity-related diseases; University of Tasmania (UTAS)
Understanding TMPRSS2:ERG gene fusions to improve prostate cancer diagnosis and treatment options; Cancer Council of Tasmania (CCT)
Utilising large Tasmanian families to determine the impact of rare genetic variation on prostate cancer.; Royal Hobart Hospital Research Foundation (RHHRF)
Biomarkers to improve outcomes in prostate cancer (BIOPC)
Donation - Prostate cancer research
Identifying biomarkers associated with clinically significant and fatal prostate cancer through genome-wide mRNA expression and methylation analyses
Targeted Next-Generation Sequencing of the Hereditary Prostate Cancer Locus 15q13-q14

Research Candidate Supervision