Web Access Research Portal

Researcher: Smith, JA (Associate Professor Jason Smith)

Fields of Research

Organic Chemical Synthesis
Plant Physiology
Natural Products Chemistry
Transition Metal Chemistry
Separation Science
Organic Chemistry
Free Radical Chemistry
Chemical Sciences
Structural Biology (incl. Macromolecular Modelling)
Algebra and Number Theory
Pharmaceutical Sciences
Plant Developmental and Reproductive Biology
Medicinal and Biomolecular Chemistry
Biologically Active Molecules
Forestry Pests, Health and Diseases
Organometallic Chemistry
Physical Organic Chemistry
Catalysis and Mechanisms of Reactions
Complementary and Alternative Medicine
Ophthalmology
Instrumental Methods (excl. Immunological and Bioassay Methods)
Tree Nutrition and Physiology
Genomics
Basic Pharmacology
Pharmacology and Pharmaceutical Sciences
Infectious Diseases
Medical Bacteriology
Horticultural Crop Protection (Pests, Diseases and Weeds)
Invertebrate Biology
Industrial Chemistry
Medical Biotechnology
Analytical Spectrometry
Main Group Metal Chemistry
Conservation and Biodiversity
Plant Cell and Molecular Biology
f-Block Chemistry
Immunological and Bioassay Methods

Research Objectives

Expanding Knowledge in the Chemical Sciences
Infectious Diseases
Expanding Knowledge in the Biological Sciences
Hardwood Plantations
Expanding Knowledge in the Environmental Sciences
Human Pharmaceutical Treatments (e.g. Antibiotics)
Air Force
Environmentally Sustainable Plant Production
Organic Industrial Chemicals (excl. Resins, Rubber and Plastics)
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Medical and Health Sciences
Control of Pests, Diseases and Exotic Species in Urban and Industrial Environments
Hearing, Vision, Speech and Their Disorders
Preventive Medicine
Rice
Industrial Chemicals and Related Products
Human Pharmaceutical Products
Environment
Grain Legumes
Control of Animal Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments
Horticultural Crops
Summer Grains and Oilseeds
Animal Protection Chemicals
Bakery Products
Veterinary Pharmaceutical Treatments (e.g. Antibiotics)
Scientific Instruments
Plant Production and Plant Primary Products
Environmentally Sustainable Manufacturing
Cancer and Related Disorders
Industrial Instruments
Vegetables
Diagnostic Methods
Environmentally Sustainable Mineral Resource Activities

Career Best Publications

A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid; Chemical Communications
A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction; Tetrahedron Letters
Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams; Organic Letters
Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids; Beilstein Journal of Organic Chemistry
Macroporous monolith supports for continuous flow capillary microreactors; Tetrahedron Letters
New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise; Organic Letters
Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis; Organic and Biomolecular Chemistry
Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis; Plant Physiology
The regioselective synthesis of aryl pyrroles; Organic and Biomolecular Chemistry

Research Publications

(RS)-2-(3,4-Methylenedioxyphenyl)-5-phenyl-3,6-dihydro-2H-pyran; Acta Crystallographica Section E
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis; European Journal of Medicinal Chemistry
ent-Labdane Diterpenoids from Dodonaea viscosa; Journal of Natural Products
A chemoenzymatic synthesis of the styryllactone (+)-goniodiol; Royal Society of Chemistry, Perkin Transactions I
A compound-based approach to unraveling auxin biosynthesis in pea; The International Plant Growth Substances Association 19th Confernece
A General and Efficient Approach to the Proposed Structures of Frog Toxins: The 5-Alkylindolizidines; Natural Product Communications
A mechanistic study on the oxidation of hydrazides: application to the tuberculosis drug isoniazid; Chemical Communications
A mild one-pot method for the conversion of carboxylic acids into the corresponding weinreb amides; Synthetic Communications
A mutation affecting the synthesis of 4-chloroindole-3-acetic acid; Plant Signalling & Behavior
A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction; Tetrahedron Letters
Acyl radical addition to benzene and related systems - a computational study; Tetrahedron
Acyl radical addition to pyridine: multiorbital interactions; Tetrahedron
Analysis of the enol–keto tautomers of indole-3-pyruvic acid; Australian Journal of Chemistry
Annulation of pyrrole: application to the synthesis of indolizidine alkaloids; Tetrahedron
Auxin Biosynthesis in Pea: Characterization of the Tryptamine Pathway; Plant Physiology
Auxin biosynthesis: are the indole-3-acetic acid and phenylacetic acid biosynthesis pathways mirror images?; Plant Physiology
Biosynthesis of the halogenated auxin, 4-chloroindole-3-acetic acid; Plant Physiology
Bitter melon protects against ER stress in LS174T colonic epithelial cells; Bmc Alternative Medicine
Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10; Redox Biology
Capillary Microreactor Catalysis Utilising Solid Organic Macroporous Monolith Supports; IC07: Royal Australian Chemical Institute Conference of the Inorganic Division
Chemistry of the synthetic strigolactone mimic GR24; Australian Journal of Chemistry
Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles; Organic & Biomolecular Chemistry
Complete stereocontrol in the synthesis of harmonine and novel analogues facilitated by a Grubbs Z-selective cross-metathesis catalysis; Australian Journal of Chemistry
Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams; Organic Letters
Convergent synthesis and preliminary biological evaluation of (+/-)-B-norrhazinal; Journal of the Royal Society of Chemistry, Perkin Transactions I
Development of a novel fluorescent tag O-2-[aminoethyl]fluorescein for the electrophoretic separation of oligosaccharides ; Analytica Chimica Acta
Exploiting multiple nucleophilic sites on pyrrole for the assembly of polyheterocyclic frameworks: application to a formal total synthesis of (+/-)-aspidospermidine; Journal of the Chemical Society, Perkins Transactions I
Extraction of Eugenol from Cloves Using an Unmodified Household Espresso Machine: An Alternative to Traditional Steam-Distillation; Journal of Chemical Education
Hydrogen/deuterium exchange on aromatic rings during atmospheric pressure chemical ionization mass spectrometry ; Rapid Communications in Mass Spectrometry
Identification of the putative aggregation pheromone components emitted by the European earwig, Forficula auricularia; Chemoecology
Identification, Synthesis and Field Testing of (3Z,6Z,9Z)-3,6,9-Henicosatriene, a Second Bioactive Component of the Sex Pheromone of the Autumn Gum Moth, Mnesampela privata; Journal of Chemical Ecology
Isolation and characterization of 1β-Acetoxypolygodial from Tasmannia Lanceolata; Asian Journal of Organic Chemistry
Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids; Beilstein Journal of Organic Chemistry
Macroporous monolith supports for continuous flow capillary microreactors; Tetrahedron Letters
Mechanistic investigation of the oxidation of hydrazides: implications for the activation of the TB drug isoniazid; Organic and Biomolecular Chemistry
Methyl 4-chloro-3,5-di-p-tolyl-1H-pyrrole-2-carboxylate dichloromethane hemisolvate; Acta Crystallographica Section E
Methyl 4-p-tolyl-1H-pyrrole-2-carboxylate; Acta Crystallographica Section E
Microfluidic devices for flow-through supported palladium catalysis on porous organic monolith; Australian Journal of Chemistry
Miniaturising Metal Catalysis at the Micrometre Level in Capillaries and Glass Chips; IC08: Royal Australian Chemical Institute Conference of the Inorganic Division
Miniaturising organic monolith supported metal catalysis at the sub-micrometre level in capillaries and glass chip; 4th EuCheMS Conference on Nitrogen Ligands in Coordination Chemistry, Metal-Organic Chemistry, Bioinorganic Chemistry and Homogeneous Catalysis
New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise; Organic Letters
Nucleophilic Acyl Substitution of Acyl Diimides; Journal of Organic Chemistry
Palladium-Catalysed Cross-Coupling and Related Reactions Involving Pyrroles; European Journal of Organic Chemistry
Palladium-mediated organic synthesis using porous polymer monolith formed in situ as a continuous catalyst support structure for application in microfluidic devices; Tetrahedron
Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis; Organic and Biomolecular Chemistry
Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species; ChemistrySelect
Reassessing the role of N-Hydroxytryptamine in auxin biosynthesis; Plant Physiology
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Supported Palladium Catalysis Using a Heteroleptic 2-Methylthiomethylpyridine -N,S- Donor Motif for Mizoroki-Heck and Suzuki-Miyaura Coupling, Including Continuous Organic Monolith in Capillary Microscale Flow-Through Mode; Tetrahedron
Synthesis and phytotoxicity of structural analogues of thaxtomin natural products; Australian Journal of Chemistry
Synthesis of heterocyclic-fused imidazoles by pyrolysis of N-heterocyclic isoxazol-5(2H)-ones; Australian Journal of Chemistry
Synthesis of nitrogen-substituted methylenecyclopropanes by strain-driven overman rearrangement of cyclopropenylmethyl trichloroacetimidates; The Journal of Organic Chemistry
The Autumn Gum Moth sex pheromone - an elusive blend of alkatrienes; ANZSMS22
The Oxidation of Pyrrole; Chemistry: An Asian Journal
The regioselective synthesis of aryl pyrroles; Organic and Biomolecular Chemistry
The role of strigolactones during plant interactions with the pathogenic fungus Fusarium oxysporum; Planta
Total synthesis of (±)-rhazinal, an alkaloid spindle toxin from Kopsia teoi; Organic and Biomolecular Chemistry
Towards high capacity latex-coated porous polymer monoliths as ion-exchange stationary phases; Analyst
UV initiated formation of polymer monoliths in glass and polymer microreactors; Sensors and Actuators B
Visible light dye-photosensitised oxidation of pyrroles using a simple LED photoreactor; Organic and Biomolecular Chemistry

Research Projects

2012: International Conference on Organic Synthesis (ICOS 19), ; University of Tasmania (UTAS)
Acoustic liquid handling robotics for bioactive compound discovery; Australian Research Council (ARC)
Biomimetic Approach to the Synthesis of Alkaloids: Dinuclear Manganese Complexes as Mimics of Cytochrome P450 in Oxidative Phenolic Coupling; University of Tasmania (UTAS)
Development of novel, host-directed antimalarial compounds; University of Tasmania (UTAS)
Investigation into Synthetic Methods for the Synthesis of Biologically Active Molecules: Pyrrolidine and Proline Derivates; University of Tasmania (UTAS)
June 2011: International Society of Heterocyclic Chemistry; University of Tasmania (UTAS)
Microreactors for Organic Synthesis; University of Tasmania (UTAS)
Neuroprotective function of novel short chain-quinones; Royal Hobart Hospital Research Foundation (RHHRF)
New Methods for the Template Mediated Synthesis of Biologically Active Compounds; University of Tasmania (UTAS)
New Synthetic Technology for the Synthesis of Biologically Important Compounds; University of Tasmania (UTAS)
Synthesis of Standards for the Monitoring of Bioremediation of Hydrocarbon Fuels; Department of Environment and Energy (Cwth) (DoEE)
The Development of New Antibiotics Targeted Towards Multi Drug Resistant Tuberculosis; University of Tasmania (UTAS)
The role of plant hormones in legume symbioses; Australian Research Council (ARC)
Beetle aggregation research
Chemical Reactivity of Opiates and Synthesis of New Opiate Derivatives
Chemika impurity characterisation - ICH guidelines
Extraction and analysis of Plant Material
Investigating the Chemical Properties of Alkaloid components
Scientific opinion on Patent
Scientific Opinion on Patent
Synthesis of Opiate Derivatives

Research Candidate Supervision

A Study of the Physical Chemistry of Acyl Radicals - Formation and Reactions
An Evaluation and Redevelopment of Current Laboratory Practices- An in Depth Study into the Differences Between Learning and Teaching Styles.
Biosynthesis of Chlorinated Auxin, A Key Plant Hormone
Chemical survey of Tasmanian land plants by Hot Pressurised Water Extraction (HPWE) targeting new molecular scaffolds for chemical modification for medicinal chemistry applications
New Synthetic Approaches to Indolizidine and Pyrrolidine Alkaloids
New Synthetic Approaches to Pyrrolidine Alkaloids
Oxazolopyridines towards the Treatment of Human African Sleeping Sickness
Oxidation of Pyrroles- Applications to the Sythesis of Biologically Active Molecules
Regioselective Modification of Pyrroles - Applications Towards Lamellarins & Pyrrolidine Analogues
Secondary Metabolites from Tasmanian Plants
Studies on the Synthesis of Biologically Active, Small Molecule Natural Products
Study of the biosynthesis and activity of auxins
Synthesis of New Derivatives Targeting Mitochondrial Disease
The Biosynthesis of Two Naturally-occurring Auxins in Pisum sativum L.
The Design and Sythesis of New Stationary Phase Materials for Use in Separation Science