Web Access Research Portal

Researcher: Foa, LC (Associate Professor Lisa Foa)

Fields of Research

Cellular Nervous System
Neurosciences
Peripheral Nervous System
Central Nervous System
Neurology and Neuromuscular Diseases
Sensory Systems
Autonomic Nervous System
Cell Physiology
Systems Physiology
Ophthalmology
Proteins and Peptides
Epidemiology
Biochemistry and Cell Biology
Nutrition and Dietetics
Medicine, Nursing and Health Curriculum and Pedagogy
Basic Pharmacology
Environmental and Occupational Health and Safety
Signal Transduction
Nutritional Physiology
Pharmaceutical Sciences
Receptors and Membrane Biology
Foetal Development and Medicine
Cell Development, Proliferation and Death
Medical Physiology
Endocrinology
Innate Immunity
Cardiology (incl. Cardiovascular Diseases)

Research Objectives

Nervous System and Disorders
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Biological Sciences
Diabetes
Expanding Knowledge in the Medical and Health Sciences
Health Related to Ageing
Cardiovascular System and Diseases
Disease Distribution and Transmission (incl. Surveillance and Response)
Clinical Health (Organs, Diseases and Abnormal Conditions)
Allied Health Therapies (excl. Mental Health Services)
Hearing, Vision, Speech and Their Disorders
Cancer and Related Disorders
Behaviour and Health
Environmental Health
Inherited Diseases (incl. Gene Therapy)
Mental Health
Infectious Diseases
Human Pharmaceutical Products
Skin and Related Disorders
Urban and Industrial Air Quality

Career Best Publications

Developmental roles for Homer: more than just a pretty scaffold; Journal of Neurochemistry
Homer expression in the Xenopus tadpole nervous system; Journal of Comparative Neurology
Homer regulates calcium signalling in growth cone turning; Neural Development
Methods in neuronal growth cone biology; TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology
STIM1 is necessary for store-operated calcium entry in turning growth cones; Journal of Neurochemistry
Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain; Differentiation
The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo; Nature Neuroscience
TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons; Molecular Neurodegeneration

Research Publications

β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain; Neurodegenerative Diseases
A case based approach to pharmacology teaching: the local experience; Proceedings of the 7th National Forum on Prevocational Medical Education
A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster); 12th International Conference on Alzheimer’s and Parkinson’s Diseases
Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain; Molecular and Cellular Neurosciences
Amyloid-beta Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2; Journal of Alzheimer's Disease
Analysis of Aβ cell interactions and uptake in hippocampal culture; 32nd Annual Meeting of the Australian Neuroscience Society
APP regulates neural stem or progenitor cell differentiation through neurogenin 2 expresssion; Federation of European Neuroscience Societies
APP stimulates neural stem/progenitor cell proliferation by increasing cystatin C secretion. (Poster); 33rd Annual Meeting Australian Neuroscience Society
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity; Journal of Alzheimer's Disease
Axonal stretch injury in vitro results in initial release of calcium from intracellular stores, prolonged calcium mismetabolism and secondary degeneration; Society for Neuroscience
Cystatin C regulates neural stem or progenitor cell proliferation (Poster); 34th Annual Meeting Australasian Neuroscience Society
Developmental roles for Homer: more than just a pretty scaffold; Journal of Neurochemistry
Disruption of protein trafficking in Alzheimer's Disease: APP, Aβ and AMPA receptors; Australian Neuroscience Society 31st Annual Meeting
Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons; Neurodegenerative Diseases
Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease; Journal of Neurochemistry
Homer 1b/c expression correlates with zebrafish olfactory system development; Journal of Neurocytology
Homer and store operated calcium entry in growth cone motility; Spinal Cord Research Symposium
Homer expression and early sensory circuit development in the zebrafish; 25th Annual Meeting of the Australian Neuroscience Society
Homer expression in the Xenopus tadpole nervous system; Journal of Comparative Neurology
Homer is a key regulator of calcium dynamics in motile growth cones; 7th IBRO World Congress of Neuroscience
Homer is a molecular correlate of growth cone turning; Australian Neuroscience Society
Homer regulates calcium signalling in growth cone turning; Neural Development
Homer1 expression in the growth cone: regulating calcium homeostasis; Australian Neuroscience Society Annual Meeting
Homer1 is necessary for maintaining calcium homeostasis in the growth cone; 2nd Brain Plasticity Symposium
How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?; Molecular and Cellular Neurosciences
Identification of novel neurotrophic-like factors: a candidate for promoting nerve regeneration in neuropathy; ANS Adelaide 2014
Inhibition of Aβ aggregation and neurotoxicity by the 39-kDa receptor-associated protein; Journal of Neurochemistry
Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury; Journal of Neurochemistry
Interaction of the receptor-associated protein (RAP) with APP and Aβ; Australian Neuroscience Society 31st Annual Meeting
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions; Biological Chemistry: Official Journal of The German Society for Biochemistry and Molecular Biology
L1 and ERM proteins are involved in regenerative sprouting following neuronal trauma in vitro; Society for Neuroscience
Low density lipoprotein receptor related proteins as regulators of neural stem and progenitor cell function; Stem Cells International
Low-density lipoprotein receptor-related proteins guide navigating PNS axons; 2015 PNS Meeting
Low-density lipoprotein receptor-related proteins in a novel mechanism of axon guidance and peripheral nerve regeneration; Journal of Biological Chemistry
LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration; Neuroscience 2014
LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration; Neuroscience 2014
Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms; Australian Neuroscience Society 31st Annual Meeting
Metallothionein I/II induces growth cone chemotaxis via an LRP­1 and LRP­2 dependent mechanism; Neuroscience 2012
Metallothionein I/II induces growth cone chemotaxis via an LRP­1 and LRP­2 dependent mechanism; Neuroscience 2012
Methods in neuronal growth cone biology; TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology
Microtubule stabilization inhibits neurite development and post-injury axonal sprouting in vitro; Society for Neuroscience
Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis; Journal of Biological Chemistry
Presenilins and the gamma-secretase: still a complex problem; Molecular Brain
Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease; Australian Neuroscience Society 31st Annual Meeting
Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells; Journal of Biological Chemistry
STIM1 is necessary for regulation of growth cone motility; Australian Neuroscience Society 31st Annual Meeting
STIM1 is necessary for store-operated calcium entry in turning growth cones; Journal of Neurochemistry
Targeted electroporation in Xenopus tadpoles in vivo - from single cells to the entire brain; Differentiation
The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons; Journal of Neuroscience Research
The ontogeny of GABA- and glutamate-like immunoreactivity in the embryonic Australian freshwater crayfish, Cherax destructor; Developmental Brain Research
The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease; Journal of Alzheimer's Disease
The role of Neurogenin2 in APP-stimulated neural stem or progenitor cell differentiation; 34th Annual Meeting Australasian Neuroscience Society
The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo; Nature Neuroscience
TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons; Molecular Neurodegeneration

Research Projects

Calcium signals in neurons: a dynamic role for the endoplasmic reticulum; The Select Foundation (SelF)
Development of a therapeutic agent for a chemotherapy-induced neuropathy; Royal Hobart Hospital Research Foundation (RHHRF)
Do metallothioneins promote and direct regenerative growth of epidermal nerve fibres in diabetic peripheral neuropathy?; Brain Foundation (BrainF)
Does Homer function in axon pathfinding within the embryonic Zebrafish olfactory system?; Clive & Vera Ramaciotti Foundation (CVRF)
Establishing a high-resolution, live cell fluoresence imaging facility at the Menzies Research Institute, University of Tasmania; Ian Potter Foundation (IPF)
Establishing a state-of-the-art 'Live Cell Recording and Imaging Facility' at Menzies Research Institute Tasmania; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Generating and characterizing a reliable rodent model type 2 diabetes; University of Tasmania (UTAS)
Hazelwood coal mine fire emissions: Are there risks for infant brain development?; University of Tasmania (UTAS)
Homer and Growth Cones: Unravelling the Jigsaw of Nerve Cell Connections in the Brain; Masonic Centenary Medical Research Foundation (MCMRF)
Homer Genes and their Role in the Wiring of the Brain's Electrical Circuit; Royal Hobart Hospital Research Foundation (RHHRF)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Mechanisms of Metallothioneins and Homer in Chemoattraction; University of Tasmania (UTAS)
Multidimensional analysis of biomarkers for the early detection of Alzheimer's disease using in vivo MRS; The Mason Foundation (ANZCT-Mason Fdn)
Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination; National Health & Medical Research Council (NHMRC)
Post Synaptic Density Scaffold proteins in the growth cone: Homer and Shank, crucial for calcium signaling; National Health & Medical Research Council (NHMRC)
Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists; National Health & Medical Research Council (NHMRC)
Repulsion and Attraction: How do LRPs turn growth cones? ; National Health & Medical Research Council (NHMRC)
The Behaviour of Learning and Memory Genes in the Ageing Brain; Masonic Centenary Medical Research Foundation (MCMRF)
The role of store-operated calcium entry in neuronal development; National Health & Medical Research Council (NHMRC)
Transient receptor potential channels, calcium and Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Understanding the cause of Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Wiring Functional Brain Circuits: Is There a Role for Homer and Metallothioneins Proteins?; University of Tasmania (UTAS)
Short chain quinones against diabetic retinopathy

Research Candidate Supervision

Deciphering the Role of Store Operated Calcium Entry in Neuronal Development in Vivo
Elucidating the Mechanisms of Cell Activity Required for Neurodevelopment
Homer, TRP Channels and Calcium- The Signalling Triad of Growth Cone Motility
LRP Receptors in a Novel Mechanism of Axon Pathfinding and Peripheral Nerve Regeneration
Molecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin
Role of Phosphoinositides in the Biology of the Amyloid Precursor Protein
STIM1 Mediates Multiple Signalling Pathways in Neuronal Growth Cones
The Role of Mitochondria in the Visual Function of Zebrafish (Danio. rerio)
Understanding the Mechanisms that Cause Alzheimer's Disease