Web Access Research Portal

Researcher: Gasperini, RJ (Dr Rob Gasperini)

Fields of Research

Cellular nervous system
Central nervous system
Peripheral nervous system
Gene mapping
Neurology and neuromuscular diseases
Cell neurochemistry
Sensory systems
Signal transduction
Bioinformatic methods development
Receptors and membrane biology
Cell development, proliferation and death
Nutritional science
Medical physiology
Cognitive neuroscience

Research Objectives

Clinical health
Expanding knowledge in the biological sciences
Expanding knowledge in the biomedical and clinical sciences
Expanding knowledge in the health sciences
Treatment of human diseases and conditions
Mental health
Other health

Career Best Publications

Research Publications

Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function; Glia
A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract; European Journal of Human Genetics
A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster); 12th International Conference on Alzheimer’s and Parkinson’s Diseases
A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents; Scientific Reports
Absence of protein polymorphism in the Ras genes of Drosophila melanogaster; Journal of Molecular Evolution
Adult myelination: wrapping up neuronal plasticity; Neural Regeneration Research
Amyloid-beta Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2; Journal of Alzheimer's Disease
Analysis of Aβ cell interactions and uptake in hippocampal culture; 32nd Annual Meeting of the Australian Neuroscience Society
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity; Journal of Alzheimer's Disease
Axonal stretch injury in vitro results in initial release of calcium from intracellular stores, prolonged calcium mismetabolism and secondary degeneration; Society for Neuroscience
Developmental roles for Homer: more than just a pretty scaffold; Journal of Neurochemistry
Disruption of protein trafficking in Alzheimer's Disease: APP, Aβ and AMPA receptors; Australian Neuroscience Society 31st Annual Meeting
Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons; Neurodegenerative Diseases
Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease; Journal of Neurochemistry
Haplotype dimorphism in a SNP collection from Drosophila melanogaster; Journal of Experimental Zoology
Homer 1b/c expression correlates with zebrafish olfactory system development; Journal of Neurocytology
Homer and store operated calcium entry in growth cone motility; Spinal Cord Research Symposium
Homer expression and early sensory circuit development in the zebrafish; 25th Annual Meeting of the Australian Neuroscience Society
Homer expression in the Xenopus tadpole nervous system; Journal of Comparative Neurology
Homer is a key regulator of calcium dynamics in motile growth cones; 7th IBRO World Congress of Neuroscience
Homer is a molecular correlate of growth cone turning; Australian Neuroscience Society
Homer regulates calcium signalling in growth cone turning; Neural Development
Homer1 expression in the growth cone: regulating calcium homeostasis; Australian Neuroscience Society Annual Meeting
Homer1 is necessary for maintaining calcium homeostasis in the growth cone; 2nd Brain Plasticity Symposium
How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?; Molecular and Cellular Neurosciences
Inhibition of Aβ aggregation and neurotoxicity by the 39-kDa receptor-associated protein; Journal of Neurochemistry
Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury; Journal of Neurochemistry
Interaction of the receptor-associated protein (RAP) with APP and Aβ; Australian Neuroscience Society 31st Annual Meeting
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions; Biological Chemistry: Official Journal of The German Society for Biochemistry and Molecular Biology
Low-density lipoprotein receptor-related proteins guide navigating PNS axons; 2015 PNS Meeting
Low-density lipoprotein receptor-related proteins in a novel mechanism of axon guidance and peripheral nerve regeneration; Journal of Biological Chemistry
LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration; Neuroscience 2014
Mechanisms of Transthyretin Aggregation and Toxicity; Protein Aggregation and Fibrillogenesis in Cerebral and Systematic Amyloid Disease, Subcellular Biochemistry 65
Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms; Australian Neuroscience Society 31st Annual Meeting
Metallothionein I/II induces growth cone chemotaxis via an LRP­1 and LRP­2 dependent mechanism; Neuroscience 2012
Metallothionein I/II induces growth cone chemotaxis via an LRP­1 and LRP­2 dependent mechanism; Neuroscience 2012
Methods in neuronal growth cone biology; TRP Channels in Drug Discovery. Methods in Pharmacology and Toxicology
Naturally occurring genetic variation affects Drosophila photoreceptor determination; Development Genes and Evolution
Neurodegeneration in Familal Amyloidotic Polyneuropathy; Clinical and Experimental Pharmacology and Physiology
Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience; Neuron
Rapid and efficient cataract gene evaluation in F0 zebrafish using CRISPR-Cas9 ribonucleoprotein complexes; Methods: A Companion to Methods in Enzymology
Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease; Australian Neuroscience Society 31st Annual Meeting
Serotonin functions as a bidirectional guidance molecule regulating growth cone motility; Cellular and Molecular Life Sciences
STIM1 is necessary for regulation of growth cone motility; Australian Neuroscience Society 31st Annual Meeting
STIM1 is necessary for store-operated calcium entry in turning growth cones; Journal of Neurochemistry
STIM1 is required for remodeling of the endoplasmic reticulum and microtubule cytoskeleton in steering growth cones; Journal of Neuroscience
The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro; Molecular and Cellular Neurosciences
The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons; Journal of Neuroscience Research
The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease; Journal of Alzheimer's Disease
TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons; Molecular Neurodegeneration
Using Lotus 1-2-3 to determine correlation of linearly related method comparison data; Computing Applications in the Biosciences

Research Projects

Calcium signals in neurons: a dynamic role for the endoplasmic reticulum; The Select Foundation (SelF)
Determining the biological consequences of Abeta binding to neurons in Alzheimer's Disease; The Select Foundation (SelF)
Do calcium blocker drugs prevent Alzheimer's disease in a transgenic mouse model? ; Dementia Australia Research Foundation Ltd (DARF)
Driverless axons: Steering Regeneration Towards The Light; National Health & Medical Research Council (NHMRC)
Driverless Axons: Steering Regeneration Towards The Light; University of Tasmania (UTAS)
Neuron to glia signalling: learning how synaptic signalling can promote CNS remyelination; National Health & Medical Research Council (NHMRC)
Repulsion and Attraction: How do LRPs turn growth cones? ; National Health & Medical Research Council (NHMRC)
The role of ion channels in beta amyloid-induced neurotoxicity; Dementia Australia Research Foundation Ltd (DARF)
Can novel mutations in Homer1 alter synaptogenesis?

Research Candidate Supervision

Deciphering the Role of Store Operated Calcium Entry in Neuronal Development in Vivo
Elucidating the Mechanisms of Cell Activity Required for Neurodevelopment
Identifying Key Regulators of Myelination in the Central Nervous System
Role of Lipoprotein Receptor-Related Proteins (LPRs) in Directing Neuronal Biology
Role of Phosphoinositides in the Biology of the Amyloid Precursor Protein
Role of the 39-kDa Receptor-Associated Protein (RAP) in Alzheimer's Disease
STIM1 Mediates Multiple Signalling Pathways in Neuronal Growth Cones
The Role of Mitochondria in the Visual Function of Zebrafish (Danio. rerio)