Web Access Research Portal

Researcher: Chuckowree, JA (Dr Jyoti Chuckowree)

Fields of Research

Central Nervous System
Neurology and Neuromuscular Diseases
Cellular Nervous System
Biological Sciences
Neurosciences
Epigenetics (incl. Genome Methylation and Epigenomics)
Pathology
Biochemistry and Cell Biology

Research Objectives

Nervous System and Disorders
Health
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Biological Sciences
Cancer and Related Disorders

Career Best Publications

Cytoskeletal and morphological alterations underlying axonal sprouting after localized transection of cortical neuron axons in vitro; Journal of Neuroscience
Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ; Cerebral Cortex
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window; Nature Protocols (Print)

Research Publications

α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury; Neurobiology of Disease
In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease; Frontiers in Cellular Neuroscience
A novel method for investigating lesion-induced changes in cortical neuron morphology in vivo
A role for ERM proteins and extracellular guidance cues in neuronal movement and the response to trauma
Acute neocortical injury induces axonal sprouting and dendritic remodelling
Alpha-internexin in Alzheimer's disease pathology demonstrates hierarchy of neuronal degeneration and neuropathic role of plaque formation
Alterations in α-internexin distribution in Alzheimer's disease and experimental models of neuronal trauma
Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ; Brain Research Bulletin
Brain healing following localised cortical injury involves restructuring of neural cytoarchitecture
Cytoskeletal and morphological alterations underlying axonal sprouting after localized transection of cortical neuron axons in vitro; Journal of Neuroscience
Cytoskeletal dynamics underlying neurite development and the sprouting response of injured neurons; Meeting of the International Society of Developmental Neuroscience
Delayed morphological alterations in a subpopulation of interneurons in the peri-wound region following focal damage to the adult rat neocortex; The 38th Annual Meeting of the Society of Neuroscience
Does Beta-Amyloid Plaque Formation Cause Structural Injury to Neuronal Processes?; Neurotoxicity Research
Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis; Neuropathology and Applied Neurobiology
Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ; Cerebral Cortex
Focal damage to the neocortex induces dendritic structural plasticity; Australian Neuroscience Society/Australian Physiological Society
Focal damage to the neocortex induces dendritic structural plasticity; Dementia, Ageing and Neurodegenerative Diseases Group Conference
Focal injury to the mature rat neocortex: The fate of nestin immunoreactive cells; 22nd Meeting of the Australian Neuroscience Society Conference
Identification and characterization of a population of motile neurons in long-term cortical culture; Cell Motility and the Cytoskeleton
In vivo imaging of short-term dendritic spine turnover in apical dendrites of layer V pyramidal neurons
In vivo imaging of short-term dendritic spine turnover in apical dendrites of layer V pyramidal neurons
In vivo two photon imaging and ultrastructural analysis of short-term dendritic spine plasticity in apical dendrites of layer V pyramical neurons; Annual Meeting for the Australian Society of Neuroscience
Intrinsic Regenerative Ability of Mature CNS Neurons; Neuroscientist
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window; Nature Protocols (Print)
Microtubule stabilization inhibits neurite development and post-injury axonal sprouting in vitro; Society for Neuroscience
Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy; Journal of Neurotrauma
Mild traumatic brain injury leads to decreased inhibition and a differential response of calretinin positive interneurons in the injured cortex; Journal of Neurotrauma
Morphological, dynamic and cytoskeletal properties underlying neurite development and axonal sprouting following localised transection of cortical axons in vitro
Motile properties of subsets of cortical neurons; 32nd Meeting of the Society for Neuroscience
Neuronal injury stimulates motility of mature cultured cortical neurons; 20th Meeting of the Australian Neuroscience Society
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer; The Prostate
The brain response to injury involves mobilization of nestin progenitors and axonal sprouting
The link between cellular changes associated with axonal injury and Alzheimer's Disease; The International Neurotrauma Symposium
The microtubule-modulating drug Epothilone D alters dendritic spine morphology in a mouse model of mild traumatic brain injury; Frontiers in Cellular Neuroscience
The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro; Molecular and Cellular Neurosciences

Research Projects

An innovative platform for studying the dynamic repertoire of the neural response to brain injury: Identifying novel therapeutic targets; Brain Foundation (BrainF)
Australasian Neuroscience Society, Adelaide; University of Tasmania (UTAS)
Developing a novel platform for studying brain trauma in vivo: Characterising post-injury reparative events and identifying targets for therapeutic intervention; University of Tasmania (UTAS)
Thalamic Lesion Induced Changes in Cortical Neuron Structure and Connectivity ; National Health & Medical Research Council (NHMRC)
Visualising the brain's response to trauma as it happens: working towards improved outcomes after traumatic brain injury; The Marian and EH Flack Trust (Flack)
Visualising the brain's response to trauma as it happens: Working towards improved outcomes after traumatic brain injury; MAIB Injury Prevention & Management Foundation (MAIB)

Research Candidate Supervision

Interneurons and Traumatic Brain Injury
Targeted Axonal Protection in Amyotrophic Lateral Sclerosis